The conductor will miss the first three weeks of the Cleveland Orchestra season, having returned unwell from its European tour.
His replacements will be Osmo Vänskä, Elim Chan and associate conductor Daniel Reith.
The deceptively youthful Franz Welser-Möst, 64, underwent treatment for a cancerous tumour a year ago. He will step down as Cleveland music director in 2027 after a record 25 years in charge.
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